Teenage fugitives Nico, Gert, Karolina, Chase and Molly are survivors. After learning their parents were super villains, the kids discover special skills of their own and topple their parents' criminal empire. Now, the Runaways meet Victor Mancha, the unknowing son of another infamous super villain, as a meddling ex-super hero support group tries to force the Runaways off the streets! Meanwhile, one Runaway deals with an unexpected legacy, and the team helps Cloak and Dagger hunt a stalker which leads to confrontations with the New Avengers and the X-Men.