Thanos, scourge of the cosmos, has acquired the Infinity Gems, granting him control over the entire universe. With the power of the gems, he destroyed half the population of all worlds, including many of the Avengers and half the Fantastic Four. The only force standing in his way is what's left of the Avengers. But how can a ragtag group of heroes and villains--including Spider-Man, Wolverine, Ms. Marvel and Doctor Doom--overpower the unstoppable?