In 1944, twenty-three-year-old Tess DeMello abruptly ends her engagement to the love of her life when she marries a mysterious stranger and moves to Hickory, North Carolina, a small town struggling with racial tension and the hardships imposed by World War II. Tess's new husband, Henry Kraft, is a secretive man who often stays out all night, hides money from his new wife, and shows no interest in making love. Tess quickly realizes she's trapped in a strange and loveless marriage with no way out. Feeling alone and adrift, Tess turns to the one person who seems to understand her, a local medium who gives her hope but seems to know more than he's letting on. When a sudden polio epidemic strikes the town, the townspeople band together to build a polio hospital. Tess, who has a nursing degree, bucks Henry's wishes and begins to work at the hospital, finding meaning in nursing the young victims. Yet at home, Henry's actions grow more alarming by the day.