When young doctor Edward Newgate arrives at Stonehearst Asylum in search of an apprenticeship, he is warmly welcomed by Superintendent Dr. Lamb and a mesmerizing woman by the name of Eliza Grave. Edward is intrigued by Lamb's modern methods of treating the insane until a series of unusual events leads him to make a horrifying discovery, exposing Lamb's utopia and pushing Edward to the limits of his conscience.