After a car crash sends repressed cartoonist Stu Miley into a coma, he and the mischievous Monkeybone, his hilarious horny alter-ego, wake up in a wacked-outaway station for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever.