Harold and Kumar take an ill-fated flight to Amsterdam, but Kumar's suspicious-looking bong is mistaken for a bomb. Their arrest prompts a racist Homeland Security official to send the boys to indefinite lockup at Guantanamo Bay. Once there, they watch as beefy guards sexually subjugate 'enemy combatants.' The guys manage to get away and make it back to the U.S., hoping the well-connected fiancé of Kumar's old girlfriend, Vanessa, can get them out of their mess. During a dangerous and grotesque odyssey to Texas, Harold and Kumar have encounters with the Ku Klux Klan, a one-eyed, inbred monster, and old friend Neil Patrick Harris, who swallows fistfuls of magic mushrooms and drags the boys to a brothel stop that goes terribly wrong.