Two eccentric scientists struggling to discover a medical breakthrough to create eternal youth; Bill Andrews is a lab biologist and famed long-distance runner. Aubrey de Grey is a genius theoretical biologist who conducts his research with a beer in hand. They differ in style and substance, but are united in their common crusade: to cure aging or die trying. As they battle their own aging and suffer the loss of loved ones, their journey toward life without end ultimately becomes personal.