Cover image for Renal physiology
Title:
Renal physiology
Author:
Koeppen, Bruce M.
Personal Author:
Edition:
5th ed.
Publication Information:
Philadelphia : Elsevier Mosby, [2013]

©2013
Physical Description:
xv, 240 pages : illustrations ; 24 cm.
Language:
English
Contents:
Physiology of body fluids -- Structure and function of the kidneys -- Glomerular filtration and renal blood flow -- Renal transport mechanisms: NaCI and water absorption along the nephron -- Regulation of body fluid osmolality: regulation of water balance -- Regulation of extracellular fluid volume and NaCI balance -- Regulation of potassium balance -- Regulation of acid-base balance -- Regulation of calcium and phosphate homeostasis -- Physiology of diuretic action -- App. A: Integrative case studies -- App. B: Normal laboratory values -- App. C: Nephron function -- App. D: Answers to self-study problems -- App. E: Answers to integrative case studies -- App. F: Review examination.
Added Author:
ISBN:
9780323086912
Format :
Book

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Library
Call Number
Material Type
Home Location
Status
Central Library QP249 .K64 2013 Adult Non-Fiction Non-Fiction Area
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Summary

Summary

Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical textbook in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives , "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers. Online access at www.StudentConsult.com makes this an even more accessible powerful learning resource.

Stay current with clear, accurate coverage of the physiology of normal renal function focusing on the needs of the student. Bridge the gap between normal function and disease with pathophysiology content throughout the book. Understand complex concepts by examining more than more than 250 clear, 2-color diagrams. Consult the book and image library online at Student Consult , anywhere you go ... perform quick searches ... add your own notes and bookmarks ... and more! Put theory into practice with "In the Clinic" or "At the Molecular Level " boxes in each chapter that explain the practical applications of fundamental knowledge. Deepen your understanding of fundamental and advanced information with an expanded collection of review questions reviewed and reorganized by chapter. Master the material more easily with learning objectives, overview boxes, key words and concepts, and chapter summaries. Apply what you've learned to real-life clinical situations with clinical cases in question-answer format at the end of each chapter.


Table of Contents

Introduction to the Kidney
1 Physiology of Body Fluids
Objectives
Physicochemical Properties of Electrolyte Solutions
Molarity and Equivalence
Osmosis and Osmotic Pressure
Osmolarity and Osmolality
Tonicity
Oncotic Pressure
Specific Gravity
Volumes of Body Fluid Compartments
Composition of Body Fluid Compartments
Fluid Exchange Between Body Fluid Compartments
Capillary Fluid Exchange
Cellular Fluid Exchange
Summary
Key Words and Concepts
Self-Study Problems
2 Structure and Function of the Kidneys
Objectives
Structure of the Kidneys
Gross Anatomy
Ultrastructure of the Nephron
Ultrastructure of the Glomerulus
Ultrastructure of the Juxtaglomerular Apparatus
Innervation of the Kidneys
Summary
Key Words and Concepts
Self-Study Problems
3 Glomerular Filtration and Renal Blood Flow
Objectives
Renal Clearance
Glomerular Filtration Rate
Glomerular Filtration
Determinants of Ultrafiltrate Composition
Dynamics of Ultrafiltration
Renal Blood Flow
Regulation of Renal Blood Flow and Glomerular Filtration Rate
Sympathetic Nerves
Angiotensin II
Prostaglandins
Nitric Oxide
Endothelin
Bradykinin
Adenosine
Natriuretic Peptides
ATP
Glucocorticoids
Histamine
Dopamine
Summary
Key Words and Concepts
Self-Study Problems
4 Renal Transport Mechanisms: NaCl and Water Reabsorption Along the Nephron
Objectives
General Principles of Membrane Transport
General Principles of Transepithelial Solute and Water Transport
NaCl, Solute, and Water Reabsorption Along the Nephron
Proximal Tubule
Henle's Loop
Distal Tubule and Collecting Duct
Regulation of NaCl and Water Reabsorption
Summary
Key Words and Concepts
Self-Study Problems
5 Regulation of Body Fluid Osmolality: Regulation of Water Balance
Objectives
Antidiuretic Hormone
Osmotic Control of AVP Secretion
Hemodynamic Control of AVP Secretion
AVP Actions on the Kidneys
Thirst
Renal Mechanisms for Dilution and Concentration of the Urine
The Role of Urea
Vasa Recta Function
Assessment of Renal Diluting and Concentrating Ability
Summary
Key Words and Concepts
Self-Study Problems
6 Regulation of Extracellular Fluid Volume and NaCl Balance
Objectives
Concept of Effective Circulating Volume
Volume-Sensing Systems
Volume Sensors in the Low-Pressure Cardiopulmonary Circuit
Volume Sensors in the High-Pressure Arterial Circuit
Hepatic Sensors
Central Nervous System Na+ Sensors
Volume Sensor Signals
Renal Sympathetic Nerves
Renin-Angiotensin-Aldosterone System
Natriuretic Peptides
AVP
Control of Renal NaCl Excretion During Euvolemia
Mechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule
Regulation of Distal Tubule and Collecting Duct Na+ Reabsorption
Control of Na+ Excretion with Volume Expansion
Control of Na+ Excretion with Volume Contraction
Edema
Alterations in Starling Forces
The Role of the Kidneys
Summary
Key Words and Concepts
Self-Study Problems
7 Regulation of Potassium Balance
Objectives
Overview of K+ Homeostasis
Regulation of Plasma [K+]
Epinephrine
Insulin
Aldosterone
Alterations of Plasma [K+]
Acid-Base Balance
Plasma Osmolality
Cell Lysis
Exercise
K+ Excretion by the Kidneys
Cellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting Duct
Regulation of K+ Secretion by the Distal Tubule and Collecting Duct
Plasma [K+]
Aldosterone
Arginine vasopressin (AVP)
Factors that Perturb K+ Excretion
Flow of Tubular Fluid
Acid-Base Balance
Glucocorticoids
Summary
Key Words and Concepts
Self-Study Problems
8 Regulation of Acid-Base Balance
Objectives
The HCO3- Buffer System
Overview of Acid-Base Balance
Renal Net Acid Excretion
HCO3- Reabsorption Along the Nephron
Regulation of H+ Secretion
Formation of New HCO3-
Response to Acid-Base Disorders
Extracellular and Intracellular Buffers
Respiratory Compensation
Renal Compensation
Simple Acid-Base Disorders
Metabolic Acidosis
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis
Analysis of Acid-Base Disorders
Summary
Key Words and Concepts
Self-Study Problems
9 Regulation of Calcium and Phosphate Homeostasis
Objectives
Calcium
Overview of Ca++ Homeostasis
Ca++ Transport along the Nephron
Regulation of Urinary Ca++ Excretion
Calcium-Sensing Receptor
Phosphate
Overview of Pi Homeostasis
Pi Transport along the Nephron
Regulation of Urinary Pi Excretion
Integrative Review of Parathyroid Hormone, Calcitriol, and Calcitonin on Ca++ and Pi Homeostasis
Summary
Key Words and Concepts
Self-Study Problems
10 Physiology of Diuretic Action
Objectives
General Principles of Diuretic Action
Sites of Action of Diuretics
Response of Other Nephron Segments
Adequate Delivery of Diuretics to Their Site of Action
Volume of the Extracellular Fluid
Diuretic Braking Phenomenon
Mechanisms of Action of Diuretics
Osmotic Diuretics
Carbonic Anhydrase Inhibitors
Loop Diuretics
Thiazide Diuretics
K+-Sparing Diuretics
Aquaretics
Effect of Diuretics on the Excretion of Water and Other Solutes
Solute-Free Water
K+ Excretion
HCO3- Excretion
Ca++ and Pi Excretion
Summary
Key Words and Concepts
Self-Study Problems
Additional Reading
Appendix A Integrative Case Studies
Appendix B Normal Laboratory Values
Appendix C Nephron Function
Appendix D Answers to Self-Study Problems
Appendix E Answers to Integrative Case Studies
Appendix F Review Examination

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