Will is locked in a mental asylum, accused of Hannibal Lecter's crimes. Now that Will knows what Hannibal is, he faces a fight to prove his own sanity and convince those closest to him that he is innocent. Jack is dealing with his own feelings about Will, and whether his protege is a killer. Looking for answers, Jack looks to Lecter, who becomes the new consultant on cases. Lecter is torn between saving himself and keeping Will close to him, despite advice from his psychiatrist to stay away.