In three horrific tales showing the world going to hell, a reclusive vampire clan and a mysterious mist lead to a deadly mission for a trespassing B.P.R.D. crew; a team investigates an abandoned warehouse in Chicago, only to discover the site of a hundred-year-old magical ritual with shocking revelations about man's prehistory; and Hellboy joins Professor O'Donnell for a trip to the secret library of a dead necromancer.