Tells the emotional true story of two men who defined the rules of their time to launch a medical revolution, set against the backdrop of the Jim Crow south. Working in 1940s Baltimore on an unprecedented technique for performing heart surgery on "blue babies", Dr. Alfred Blalock and lab technician Vivien Thomas form an impressive team. As Blalock and Thomas invent a new field of medicine, saving thousands of lives in the process, social pressures threaten to undermine their collaboration and tear them apart.