Andy Stitzer is 40 years old. He has a cushy job stamping invoices at an electronics superstore, a nice apartment with a proud collection of action figures and comic books, good friends, and a nice attitude. But there's just one little thing he hasn't quite gotten around to doing yet. Andy's never had sex. He does not think it is such a big deal, but for Andy's buddies at the store, it sure is. They consider it their duty to help Andy out of his dire situation and go to great lengths to help him. But nothing proves effective enough to lure their friend out of lifelong chastity until he meets Trish. Andy's friends are psyched by the possibility that 'it' may finally happen - until they hear that Andy and Trish have begun their relationship based on a mutual no-sex policy.