Defining the experimental program -- The hypothesis as a framework for scientific projects : is critical rationalism critical? -- Scientific settings in which a hypothesis is not practical -- The problem/question as a framework for scientific projects : an invitation for inductive reasoning -- What constitutes an acceptable answer to an experimental question? -- How experimental conclusions are used to represent reality : model building -- Establishing a system for experimentation -- Designing the experiment : definitions, time courses, and experimental repeats -- Validating a model : the ability to predict the future -- Designing the experimental project : a biological example -- Experimental repetition : the process of acquiring data to model future outcomes -- The requirement for the negative control -- The requirement for the positive control -- Method and reagent controls -- Subject controls -- Assumption controls -- Experimentalist controls : establishing a claim to an objective perspective -- A description of biological empiricism -- A short synopsis.