When Nate is invited to a big family reunion in Missouri, he sees it as an opportunity to reconnect with his estranged wife and growing children. Nate takes delivery on an expensive new SUV, persuades his wife, Dorothy, to tag along, and packs up his three kids for what he thinks will be a leisurely drive from L.A. to St. Louis. However, between his wary wife, arguing kids, angry police officers, bizarre hitchhikers, bad diner food, and an unfortunate run-in with a cement mixer, getting from point A to point B proves to be just short of a nightmare.