Cover image for Medicinal chemistry : an introduction
Medicinal chemistry : an introduction
Thomas, Gareth, Dr.
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Publication Information:
Chichester ; New York : Wiley, [2000]

Physical Description:
xxvii, 539 pages : illustrations ; 24 cm
Introduction -- Drug discovery by design -- Drug solubility -- Biological membranes -- Pharmacokinetics -- Enzymes -- Complexes and chelating agents -- Receptors and messengers -- Drug metabolism -- Nucleic acids -- Nitric oxide -- An introduction to organic drug and analogue synthesis.

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RS403 .T447 2000 Adult Non-Fiction Central Closed Stacks

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Medicinal Chemistry: An Introduction, provides a comprehensive, balanced introduction to this exciting, evolving and multi-disciplinary field. This text assumes little prior knowledge of medicinal chemistry and keeps the approach as simple as possible. Focusing on the chemical principles used for drug discovery and design, it also covers human biology where relevant. Each chapter has a summary of its contents, self-assessment questions, numerous examples and applications.

Reviews 1

Choice Review

Thomas (Univ. of Portsmouth, UK) has substantially revised the 2000 edition of Medicinal Chemistry and has included new chapters titled "Drugs from Natural Sources" and "Drug Development and Production." The first three chapters provide a clear idea of the basics of medicinal chemistry. Some chapters, such as "Drug Metabolism," can easily be understood by undergraduates, although most others assume a higher-level knowledge. The chapters that discuss combinatorial chemistry and computer-aided drug design would be extremely difficult for undergraduates who have taken only a basic organic chemistry course. The chapter on quantitative structure-activity relationship studies requires some knowledge of specific mathematical/statistical concepts. Overall, this book is more suitable for introductory graduate-level curricula than for undergraduate coursework. However, it will serve as a good reference for any medicinal chemistry course; it is a good complement to Richard Silverman's Organic Chemistry of Drug Design and Drug Action (1992). Summing Up: Recommended. Upper-division undergraduates through professionals. S. Rajaraman Richard Stockton College of New Jersey

Table of Contents

Chapter 1 An Introduction to Drugs, their Action and Discovery.
Chapter 2 Drug Structure and Solubility.
Chapter 3 Structure-activity and quantitative structures relationships.
Chapter 4 Computer aided drug design.
Chapter 5 Combinatorial Chemistry.
Chapter 6 Drugs from natural sources.
Chapter 7 Biological Membranes.
Chapter 8 Receptors and Messengers.
Chapter 9 Enzymes.
Chapter 10 Nucleic Acids.
Chapter 11 Pharmacokinetics.
Chapter 12 Drug metabolism.
Chapter 13 Complexes and chelating agents.
Chapter 14 Nitric oxide.
Chapter 15 An Introduction to drug and analogue synthesis.
Chapter 16 Drug Development and Production.
Selective further reading.
Answers to Questions.