Cover image for Goodman & Gilman's the pharmacological basis of therapeutics.
Title:
Goodman & Gilman's the pharmacological basis of therapeutics.
Author:
Goodman, Louis S. (Louis Sanford), 1906-2000.
Edition:
Tenth edition / editors, Joel G. Hardman, Lee E. Limbird ; consulting editor, Alfred Goodman Gilman.
Publication Information:
New York : McGraw-Hill, [2001]

©2001
Physical Description:
xxvii, 2148 pages : illustrations ; 26 cm
Language:
English
ISBN:
9780071354691

9780071124324
Format :
Book

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RM300 .G644 2001 10 TH. ED. Adult Non-Fiction Non-Fiction Area-Reference
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Summary

Summary

Goodman & Gilman is the Bible of pharmacology as it has been since the first edition written by Louis Goodman and Alfred Gilman and published in 1941. It is the definitive textbook for all medical and pharmacy students and is a must have purchase for residents in internal medicine and pharmacologists. The book is a higher level than our Katzung and should be considered as the perfect accompaniment to the new Harrison. The objective of this textbook/ reference work is to provide a comprehensive and up-to-date correlation of pharmacology with related medical sciences, a reinterpretation of the actions and uses of drug from the view point of the latest advances in medicine and pace emphasis on the application of pharmacodynamics to therapeutics. Throughout its history, Goodman & Gilman has become more than a textbook. It is a working template for effective and rational prescribing of drugs in daily practice. The careful balance of basic science and clinical application has guided students and practitioners to a better understanding of how and why drugs work. The information is presented in a style that reads with maximum clarity and purpose. Transformed and expanded in the last ed


Table of Contents

Iain L. O. BuxtonKathleen M. Giacomini and Yuichi SugiyamaFrank J. Gonzalez and Robert H. TukeyMary V. Relling and Kathleen M. GiacominiJohn A. OatesThomas C. Westfall and David P. WestfallJoan Heller Brown and Palmer TaylorPalmer TaylorPalmer TaylorThomas C. Westfall and David P. WestfallElaine Sanders-Bush and Steven E. MayerFloyd E. BloomAlex S. Evers and C. Michael Crowder and Jeffrey R. BalserWilliam A. Catterall and Ken MackieBrett A. Simon and Eric J. Moody and Roger A. JohnsDennis S. Charney and S. John Mihic and R. Adron HarrisRoss J. BaldessariniRoss J. Baldessarini and Frank I. TaraziJames O. McNamaraDavid G. Standaert and Anne B. YoungHoward B. Gutstein and Huda AkilMichael F. Fleming and S. John Mihic and R. Adron HarrisCharles P. O'BrienRandal A. Skidgel and Ervin G. ErdosEmer M. Smyth and Anne Burke and Garret A. FitzGeraldAnne Burke and Emer M. Smyth and Garret A. FitzGeraldBradley J. UndemEdwin K. JacksonEdwin K. JacksonEdwin K. JacksonThomas MichelBrian B. HoffmanThomas P. Rocco and James C. FangDan M. RodenRobert W. Mahley and Thomas P. BersotWillemijntje A. Hoogerwerf and Pankaj Jay PasrichaPankaj Jay PasrichaJoseph H. Sellin and Pankaj Jay PasrichaTheresa A. Shapiro and Daniel E. GoldbergMargaret A. Phillips and Samuel L. Stanley, Jr.Alex Loukas and Peter J. HotezHenry F. ChambersWilliam A. Petri, Jr.William A. Petri, Jr.Henry F. ChambersHenry F. ChambersWilliam A. Petri, Jr.John E. BennettFrederick G. HaydenCharles FlexnerBruce A. Chabner and Philip C. Amrein and Brian Druker and M. Dror Michaelson and Constantine S. Mitsiades and Paul E. Goss and David P. Ryan and Sumant Ramachandra and Paul G. Richardson and Jeffrey G. Supko and Wyndham H. WilsonAlan M. Krensky and Flavio Vincenti and William M. BennettKenneth Kaushansky and Thomas J. KippsPhilip W. Majerus and Douglas M. TollefsenKeith L. Parker and Bernard P. SchimmerAlan P. Farwell and Lewis E. BravermanDavid S. Loose and George M. StancelPeter J. SnyderBernard P. Schimmer and Keith L. ParkerStephen N. DavisPeter A. FriedmanLindy P. Fox and Hans F. Merk and David R. BickersJeffrey D. Henderer and Christopher J. RapuanoCurtis D. KlaassenCurtis D. KlaassenIain L. O. Buxton
Contributorsp. xi
Consultants to the Editorsp. xvii
Prefacep. xxi
Preface to the First Editionp. xxiii
Section I General Principlesp. 1
1 Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Eliminationp. 1
2 Membrane Transporters and Drug Responsep. 41
3 Drug Metabolismp. 71
4 Pharmacogeneticsp. 93
5 The Science of Drug Therapyp. 117
Section II Drugs Acting at Synaptic and Neuroeffector Junctional Sitesp. 137
6 Neurotransmission: The Autonomic and Somatic Motor Nervous Systemsp. 137
7 Muscarinic Receptor Agonists and Antagonistsp. 183
8 Anticholinesterase Agentsp. 201
9 Agents Acting at the Neuromuscular Junction and Autonomic Gangliap. 217
10 Adrenergic Agonists and Antagonistsp. 237
11 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonistsp. 297
Section III Drugs Acting on the Central Nervous Systemp. 317
12 Neurotransmission and the Central Nervous Systemp. 317
13 General Anestheticsp. 341
14 Local Anestheticsp. 369
15 Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Heliump. 387
16 Hypnotics and Sedativesp. 401
17 Drug Therapy of Depression and Anxiety Disordersp. 429
18 Pharmacotherapy of Psychosis and Maniap. 461
19 Pharmacotherapy of the Epilepsiesp. 501
20 Treatment of Central Nervous System Degenerative Disordersp. 527
21 Opioid Analgesicsp. 547
22 Ethanolp. 591
23 Drug Addiction and Drug Abusep. 607
Section IV Autacoids: Drug Therapy of Inflammationp. 629
24 Histamine, Bradykinin, and Their Antagonistsp. 629
25 Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factorp. 653
26 Analgesic-Antipyretic Agents; Pharmacotherapy of Goutp. 671
27 Pharmacotherapy of Asthmap. 717
Section V Drugs Affecting Renal and Cardiovascular Functionp. 737
28 Diureticsp. 737
29 Vasopressin and Other Agents Affecting the Renal Conservation of Waterp. 771
30 Renin and Angiotensinp. 789
31 Treatment of Myocardial Ischemiap. 823
32 Therapy of Hypertensionp. 845
33 Pharmacotherapy of Congestive Heart Failurep. 869
34 Antiarrhythmic Drugsp. 899
35 Drug Therapy for Hypercholesterolemia and Dyslipidemiap. 933
Section VI Drugs Affecting Gastrointestinal Functionp. 967
36 Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Diseasep. 967
37 Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Diseasep. 983
38 Pharmacotherapy of Inflammatory Bowel Diseasep. 1009
Section VII Chemotherapy of Parasitic Infectionsp. 1021
39 Chemotherapy of Protozoal Infections: Malariap. 1021
40 Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infectionsp. 1049
41 Chemotherapy of Helminth Infectionsp. 1073
Section VIII Chemotherapy of Microbial Diseasesp. 1095
42 General Considerations of Antimicrobial Therapyp. 1095
43 Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infectionsp. 1111
44 Penicillins, Cephalosporins, and Other [beta]-Lactam Antibioticsp. 1127
45 Aminoglycosidesp. 1155
46 Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agentsp. 1173
47 Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosyp. 1203
48 Antifungal Agentsp. 1225
49 Antiviral Agents (Nonretroviral)p. 1243
50 Antiretroviral Agents and Treatment of HIV Infectionp. 1273
Section IX Chemotherapy of Neoplastic Diseasesp. 1315
51 Antineoplastic Agentsp. 1315
Section X Immunomodulatorsp. 1405
52 Immunosuppressants, Tolerogens, and Immunostimulantsp. 1405
Section XI Drugs Acting on the Blood and the Blood-Forming Organsp. 1433
53 Hematopoietic Agents: Growth Factors, Minerals, and Vitaminsp. 1433
54 Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugsp. 1467
Section XII Hormones and Hormone Antagonistsp. 1489
55 Pituitary Hormones and Their Hypothalamic Releasing Factorsp. 1489
56 Thyroid and Antithyroid Drugsp. 1511
57 Estrogens and Progestinsp. 1541
58 Androgensp. 1573
59 Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormonesp. 1587
60 Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreasp. 1613
61 Agents Affecting Mineral Ion Homeostasis and Bone Turnoverp. 1647
Section XIII Dermatologyp. 1679
62 Dermatological Pharmacologyp. 1679
Section XIV Ophthalmologyp. 1707
63 Ocular Pharmacologyp. 1707
Section XV Toxicologyp. 1739
64 Principles of Toxicology and Treatment of Poisoningp. 1739
65 Heavy Metals and Heavy-Metal Antagonistsp. 1753
Appendices
I Principles of Prescription Order Writing and Patient Compliancep. 1777