Cover image for Mechanism synthesis
Mechanism synthesis
Taylor, Peter G., 1951-
Publication Information:
Cambridge : Royal Society of Chemistry, [2002]

Physical Description:
368 pages : illustrations ; 27 cm + 1 cd-rom (4 3/4 in.).
General Note:
"This publication forms part of an Open University course, S205 The Molecular World"--T.p. verso.
Format :


Call Number
Material Type
Home Location
Item Holds
QH506 .M42 2002 Book and Software Set Non-Fiction Area-Oversize

On Order



This book pursues possible strategies for synthesising mainly organic compounds, particularly those of interest to the health sector and related industries. Topics covered include addition reactions of aldehydes and ketones; the use of organometallic reagents to form carbon-carbon bonds (eg Grignard reagents); and radical reactions, including selectivity and chain reactions. Retrosynthetic analysis is introduced as a strategy for developing syntheses, along with biochemical pathways. Mechanism and Synthesis concludes with a Case Study on polymers, which demonstrates how chain reactions can be used to build up useful materials with specific properties, such as contact lenses. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

Reviews 1

Choice Review

This book is one of a series written on independent study for students in the chemistry/biology sequence of the British Open University. A book of this type must be written with exceptional clarity, considering the fact that readers will not have immediate access to course instructors. Problems must be carefully chosen and their answers clearly explained. The book meets both of these requirements quite well. A diligent reader could gain a fairly good knowledge of the concepts covered. These include some of the most important in organic chemistry: the carbonyl group, synthetic applications of organometallic compounds, radicals, organic synthetic strategy, synthesis and biosynthesis of terpenes and steroids, and polymers. However, the book would be inappropriate as a resource for a full-year course in organic chemistry because important topics such as proteins, carbohydrates, aromatic substitution, conformational analysis, and spectroscopy are covered sketchily or not at all. Some of these do, however, appear to be discussed in the other seven books in the series. A useful supplement to a standard US course resource, since it contains some nice enrichment material not often found in standard works. ^BSumming Up: Recommended. General readers; lower- and upper-division undergraduates; two-year technical program students. A. Fry Wesleyan University

Table of Contents

Part 1 Carbonyl Compounds
Carbonyl Compounds in Context
The Structure of the Carbonyl Group
Nucleophilic Attack at the Carbonyl Group
Part 2 Synthetic Applications of Organometallic Compounds
Organomagnesium Halides
Organolithium and Organosodium Compounds
Organocopper Compounds
Review of the Reactivities of Organometallic Reagents
Organoboron Compounds
Part 3 Radical Reactions in Organic Synthesis
Reactions of Radicals
Radical-Radical Coupling Reactions (Radical Combinations)
Radical Chain Reactions
Radical Fragmentation Reactions
An Application
Part 4 Strategy and Methodology in Organic Synthesis
Synthesis in Organic Chemistry
Requirements for Synthesis
Planning a Synthesis
Simple Disconnections: C-X Bonds
Simple Disconnections: C-C Bonds
CD-ROM Activity
Control in Synthesis
Further Factors Affecting the Choice of a Synthetic Route
Synthesis of a Drug
Part 5 Synthesis and Biosynthesis: Terpenes and Steroids
The Laboratory Synthesis of Monoterpenes
A Biochemical Interlude
The Synthesis of Terpenes in Living Systems
The Chemistry of Terpene Biosynthesis
From Triterpenes to Steroids
Case Study: Polymer Chemistry