Ch. 1. Basic concepts -- Ch. 2. Distribution of sickle cell disease -- Ch. 3. Nomenclature and genetics of sickle cell disease -- Ch. 4. Diagnosis of sickle cell disease -- Ch. 5. Pathophysiology of sickle cell disease -- Ch. 6. Historical aspects -- Ch. 7. The bone marrow -- Ch. 8. The blood -- Ch. 9. The liver and gallbladder -- Ch. 10. The spleen -- Ch. 11. The immune system -- Ch. 12. The gut and abdomen -- Ch. 13. Cardiovascular system -- Ch. 14. Pulmonary system -- Ch. 15. Leg ulceration -- Ch. 16. Bone and joint lesions -- Ch. 17. The painful crisis -- Ch. 18. Renal manifestations -- Ch. 19. Priapism -- Ch. 20. The nervous system -- Ch. 21. The eyes -- Ch. 22. Physical and sexual development -- Ch. 23. Pregnancy and contraception -- Ch. 24. Endocrine system, metabolism, and nutrition -- Ch. 25. Homozygous sickle cell disease -- Ch. 26. Sickle cell-haemoglobin C disease -- Ch. 27. Sickle cell-β thalassaemia -- Ch. 28. Other forms of sickle cell disease -- Ch. 29. Sickle cell - hereditary persistence of fetal haemoglobin -- Ch. 30. The sickle cell trait -- Ch. 31. General supportive measures -- Ch. 32. Transfusion -- Ch. 33. Attempts to inhibit sickling -- Ch. 34. Surgery and anaesthesia -- Ch. 35. Screening and sickle cell clinics -- Ch. 36. Age and patterns of clinical involvement -- Ch. 37. Causes of death -- Ch. 38. Natural history.