Cover image for Sickle cell disease
Sickle cell disease
Serjeant, Graham R.
Personal Author:
Third edition.
Publication Information:
Oxford ; New York : Oxford University Press, [2001]

Physical Description:
xix, 772 pages : illustrations, maps ; 24 cm.
Ch. 1. Basic concepts -- Ch. 2. Distribution of sickle cell disease -- Ch. 3. Nomenclature and genetics of sickle cell disease -- Ch. 4. Diagnosis of sickle cell disease -- Ch. 5. Pathophysiology of sickle cell disease -- Ch. 6. Historical aspects -- Ch. 7. The bone marrow -- Ch. 8. The blood -- Ch. 9. The liver and gallbladder -- Ch. 10. The spleen -- Ch. 11. The immune system -- Ch. 12. The gut and abdomen -- Ch. 13. Cardiovascular system -- Ch. 14. Pulmonary system -- Ch. 15. Leg ulceration -- Ch. 16. Bone and joint lesions -- Ch. 17. The painful crisis -- Ch. 18. Renal manifestations -- Ch. 19. Priapism -- Ch. 20. The nervous system -- Ch. 21. The eyes -- Ch. 22. Physical and sexual development -- Ch. 23. Pregnancy and contraception -- Ch. 24. Endocrine system, metabolism, and nutrition -- Ch. 25. Homozygous sickle cell disease -- Ch. 26. Sickle cell-haemoglobin C disease -- Ch. 27. Sickle cell-β thalassaemia -- Ch. 28. Other forms of sickle cell disease -- Ch. 29. Sickle cell - hereditary persistence of fetal haemoglobin -- Ch. 30. The sickle cell trait -- Ch. 31. General supportive measures -- Ch. 32. Transfusion -- Ch. 33. Attempts to inhibit sickling -- Ch. 34. Surgery and anaesthesia -- Ch. 35. Screening and sickle cell clinics -- Ch. 36. Age and patterns of clinical involvement -- Ch. 37. Causes of death -- Ch. 38. Natural history.
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Call Number
Material Type
Home Location
Item Holds
RC641.7.S5 S463 2001 Adult Non-Fiction Non-Fiction Area-Reference

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Sickle cell disease is one of the 'grand' diseases in the terminology of Victorian pathology, because its widespread and multitudinous manifestations may affect any organ system in the body. It has served as a model of molecular disease being one of the first genetic disorders to be explainedat the molecular level. Since publication of the Second Edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality.As Director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a singlegenotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management.

Author Notes

Graham R Serjeant , Director, Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica

Table of Contents

1 Basic Concepts
2 Distribution of Sickle Cell Disease
3 Nomenclature and Genetics of Sickle Cell Disease
4 Diagnosis of Sickle Cell Disease
5 Pathophysiology of Sickle Cell Disease
6 Historical Aspects
7 The Bone Marrow
8 The Blood
9 The Liver
10 The Spleen
11 The Immune System
12 The Gut
13 Cardiovascular System
14 Pulmonary System
15 Leg Ulceration
16 Bone and Joint Lesions
17 The Painful Crisis
18 Renal Manifestations
19 Priapism
20 The Nervous System
21 The Eyes
22 Physical and Sexual Development
23 Pregnancy and Contraception
24 Homozygous Sickle Cell Disease
25 Sickle Cell--Haemoglobin C Disease
26 Sickle Cell--Beta Thalassaemia
27 Other Forms of Sickle Cell Disease
28 Sickle Cell--Hereditary Persistence of Fetal Haemoglobin
29 The Sickle Cell Trait
30 Age and Patterns of Clinical Involvement
31 Causes of Mortalite
32 General Supportive Measures
33 Blood Transfusions
34 Therapeutic Attempts to Inhibit Sickling
35 Surgery and Anaesthesia
36 Screening and Sickle Cell Clinics
37 The Epidemiology of Sickle Cell Disease