Cover image for NMR and chemistry : an introduction to modern NMR spectroscopy
Title:
NMR and chemistry : an introduction to modern NMR spectroscopy
Author:
Akitt, J. W.
Personal Author:
Edition:
Fourth edition.
Publication Information:
Cheltenham, U.K. : S. Thornes, [2000]

©2000
Physical Description:
xvi, 400 pages : illustrations ; 25 cm
Language:
English
Added Author:
ISBN:
9780748743445
Format :
Book

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Status
Central Library QD96.N8 A37 2000 Adult Non-Fiction Central Closed Stacks
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Summary

Summary

Keeping mathematics to a minimum, this book introduces nuclear properties, nuclear screening, chemical shift, spin-spin coupling, and relaxation. It is one of the few books that provides the student with the physical background to NMR spectroscopy from the point of view of the whole of the periodic table rather than concentrating on the narrow applications of 1H and 13C NMR spectroscopy. Aids to structure determination, such as decoupling, the nuclear Overhauser effect, INEPT, DEPT, and special editing, and two dimensional NMR spectroscopy are discussed in detail with examples, including the complete assignment of the 1H and 13C NMR spectra of D-amygdain.

The authors examine the requirements of a modern spectrometer and the effects of pulses and discuss the effects of dynamic processes as a function of temperature or pressure on NMR spectra. The book concludes with chapters on some of the applications of NMR spectroscopy to medical and non-medical imaging techniques and solid state chemistry of both I = F1/2 and I > F1/2 nuclei. Examples and problems, mainly from the recent inorganic/organometallic chemistry literature support the text throughout. Brief answers to all the problems are provided in the text with full answers at the end of the book.


Author Notes

Dr. James Wells Akitt was formerly Senior Research Officer at the University of Leeds, UK.


Table of Contents

Abbreviationsp. ix
Preface to the fourth editionp. xv
1 The theory of nuclear magnetizationp. 1
1.1 The properties of the nucleus of an atomp. 1
1.2 The nucleus in a magnetic fieldp. 5
1.3 The source of the NMR signalp. 6
1.4 A basic NMR spectrometerp. 12
1.5 Questionsp. 14
2 The magnetic field at the nucleus: nuclear screening and the chemical shiftp. 17
2.1 Effects due to the moleculep. 17
2.2 Isotope effectsp. 24
2.3 Effects due to unpaired electronsp. 27
2.4 The chemical shiftp. 32
2.5 Notes on sample preparation, standardization and solvent and temperature effectsp. 36
2.6 Questionsp. 43
3 Internuclear spin-spin couplingp. 45
3.1 The mutual effects of nuclear magnets on resonance positionsp. 45
3.2 The appearance of multiplets arising from spin-spin couplingp. 47
3.3 Spin-spin coupling satellitesp. 61
3.4 The description of spin systemsp. 65
3.5 Second-order effectsp. 69
3.6 Questionsp. 86
4 Nuclear magnetic relaxationp. 101
4.1 Relaxation processes in assemblies of nuclear spinsp. 101
4.2 Dipole-dipole relaxationp. 104
4.3 Quadrupolar relaxationp. 109
4.4 Spin rotation relaxation: detailed molecular motionp. 117
4.5 Chemical shift anisotropy relaxationp. 120
4.6 Scalar relaxationp. 121
4.7 Examples of [superscript 13]C relaxation timesp. 124
4.8 Questionsp. 126
5 The spectrometerp. 129
5.1 The magnet and field homogeneityp. 130
5.2 The probep. 134
5.3 Field-frequency lockp. 135
5.4 The transmitterp. 137
5.5 The detection systemp. 139
5.6 Production of the spectrump. 147
5.7 Rapid multiple pulsingp. 156
5.8 Manipulation of collected datap. 158
5.9 Questionsp. 166
6 Making the spins dancep. 167
6.1 Decouplingp. 167
6.2 Composite pulsesp. 180
6.3 Refocusing pulsep. 182
6.4 Questionsp. 188
7 NMR spectra of exchanging and reacting systemsp. 189
7.1 Systems at equilibriump. 189
7.2 Reaction monitoring of systems not at equilibriump. 224
7.3 Questionsp. 230
8 Multiple resonance and one-dimensional pulse sequencesp. 233
8.1 Decoupling difference spectroscopyp. 234
8.2 The nuclear Overhauser effectp. 237
8.3 One-dimensional multipulse sequencesp. 253
8.4 Exercises in spectral interpretationp. 267
9 Two-dimensional NMR spectroscopyp. 273
9.1 J-resolved two-dimensional NMR spectroscopyp. 278
9.2 Homonuclear COSY NMR spectroscopyp. 282
9.3 Heteronuclear COSY NMR spectroscopyp. 290
9.4 HOHAHA or TOCSYp. 294
9.5 Two-dimensional Inadequatep. 296
9.6 Overhauser and magnetization transfer based two-dimensional NMR spectroscopyp. 296
9.7 Inverse detectionp. 304
9.8 Three-dimensional NMR spectroscopyp. 312
9.9 Questionsp. 312
10 Magnetic resonance imaging and biomedical NMRp. 335
10.1 Producing an imagep. 335
10.2 Whole body imagingp. 337
10.3 Diffusion and flowp. 341
10.4 Chemical shift imagingp. 342
10.5 Biological uses of imaging - imaging microscopyp. 346
10.6 Industrial uses of imaging techniquesp. 348
10.7 Biomedical NMRp. 350
11 High-resolution solid-state NMRp. 355
11.1 Magic angle spinningp. 357
11.2 Spin-1/2 nuclei with low magnetogyric ratiosp. 359
11.3 I = 1/2 nuclei with high magnetogyric ratiosp. 365
11.4 MAS of quadrupolar nucleip. 368
11.5 Some applicationsp. 376
11.6 Deuterium, an integral-spin nucleusp. 381
11.7 Questionsp. 383
Bibliographyp. 385
Answers to Questionsp. 391
Indexp. 397

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