Cover image for The syndrome
The syndrome
Case, John, 1943-
Personal Author:
First edition.
Publication Information:
New York : Ballantine Books, [2001]

Physical Description:
455 pages ; 25 cm
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X Adult Fiction Central Closed Stacks

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A promising research fellow for a venerable think tank in Zurich has just filed his last report, as he is forced into a grisly experiment. . . . A seductive young woman travels to Florida and, from her hotel room window, coolly sharpshoots an old man in a wheelchair as he basks in the late afternoon sun. . . . A psychologist who helps patients confront and dispel past trauma through hypnosis battles his own silent demons. . . .  In The Syndrome, John Case combines these intriguing elements into a pulse-pounding, mind-twisting new thriller. Dr. Jeff Duran suffers from severe panic attacks when he ventures too far outside his home office. At times, he remembers phrases of a foreign language he has never learned. And there are curious memories he cannot explain of distinct smells, music, the spray of ocean sailing. But no sooner do these senses and images begin to surface than they disappear. Then, after a patient commits suicide, Duran's life spirals out of control. The victim's half-sister, Adrienne Cope, blames Duran for filling her sister's head with "recovered" memories of horrific childhood abuse. But Adrienne soon discovers some shocking facts about him--facts that even he is unaware of. The stakes are raised when unknown assassins burst into Duran's office and bloodshed ensues. But who is their target: Adrienne or Duran? Running for their very lives, forced to trust each other, they must now work together to unlock the reason why one or both of them is marked for death. For beneath the intrigue lies a dark conspiracy that stretches halfway around the world-- and a sinister plot that could change the course of history. A relentlessly paced thriller in which nothing is what it seems, no one can be trusted, and nothing is secure--especially one's own memories.  The Syndrome is a chillingly, brilliantly conceived novel from a proven master of suspense.

Reviews 3

Booklist Review

How reliable is memory? That's the central question in the latest technothriller by Case, author of the popular Genesis Code (1997). Nico, a gorgeous young woman who coolly assassinates a man outside her Florida penthouse hotel room, is by day a disturbed single gal living in DC under the close supervision of her psychologist, Dr. Jeff Duran. While under hypnosis, Nico reveals startling details--so grotesque as to sound delusional--about an abusive childhood. But she never reveals her other life as an assassin, and the reader isn't really sure whether Nico even recognizes that she has an alter ego, most likely because her myriad medications distort her memory. Enter Adrienne, Nico's half-sister, who denies the abuse that Nico insists is part of their collective childhood. A traumatic episode forces Adrienne, a young attorney on the partner track, to delve more deeply into her sister's past, where she begins to uncover the strange pieces of both Nico's and Dr. Duran's troubled lives. An interesting blend of sci-fi and mystery, Case's thriller presents a disturbing yet compelling look at science and the psychology of the mind. --Mary Frances Wilkens

Publisher's Weekly Review

The always intriguing Case (The Genesis Code; The First Horseman) poses another troubling question for the ages in his latest biospeculative thriller. Just what happened to the U.S. government's secret mind-control experiments of the 1960s? In this diverting fictional juggernaut, a shadowy private enterprise, the Prudhomme Clinic, took over where the government left off. It is now kidnapping people, wiping their memories clean and turning them into assassins who target international leaders whom the Prudhomme believes are destabilizing world order. The whole operation, however, is jeopardized when one recreated human, Jeff Duran, manages to break the spell and start questioning who he is, and more importantly, who he was before a computer chip was implanted in his brain. He teams up in his quest with Adrienne Cope, a Washington, D.C., lawyer who has been baffled by the suicide of her sister, who, unbeknownst to Adrienne, was one of the Prudhomme's most skilled killers. Soon after the two begin poking around, they find their lives are in peril. They begin a frantic search for information, dodging attempts on their lives and making one bone-chilling discovery after another. They ultimately find themselves rushing off to Switzerland not only to confront the Prudhomme's leader, but to save the life of Nelson Mandela, who has been targeted for assassination. Explanations of the history and techniques of mind-control experiments as well as the psychology of amnesia add a realistic overlay to what otherwise might have been a fairly formulaic thriller. Case, revealed here for the first time to be the husband-and-wife writing team of Jim and Carolyn Hougan of Virginia, shows the sort of sure-handed storytelling that made their first two books such hot sellers. National ad campaign; author appearances in Washington, D.C., and Baltimore. (May 1) (c) Copyright PWxyz, LLC. All rights reserved

Library Journal Review

With the release of this third thriller (after Genesis Code), Ballantine reveals that Case is a pseudonym for husband-and-wife team Jim and Carolina Hougan. This is the fast-paced story of Adrienne, a young lawyer who has just become reacquainted with her estranged sister, Nikki. But when Adrienne arrives at Nikki's apartment for lunch, she finds her sister dead, an apparent suicide by electrocution in her tub. Adrienne blames therapist Jeff Duran, who she believes hypnotized Nikki and inserted "recovered" memories of a childhood tainted with gruesome sexual abuse. But Adrienne's attempt to nail Duran only plunges them both into danger when they become the targets of unknown killers. Running for their lives, Adrienne and Duran uncover a conspiracy involving the use of brain implants to control people and manipulate them into committing unthinkable political crimes. This X-Files-like concept is rendered with believable medical and psychological explanations. If readers are looking for a little excitement with a dash of romance, they'll find it here. Recommended for most fiction collections. [Previewed in Prepub Alert, LJ 1/01.] Shirley Gibson Coleman, Ann Arbor Dist. Lib., MI (c) Copyright 2010. Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.



Zurich June 16, 1996 It wasn't the Grande Jatte. Not exactly. It wasn't even the afternoon. Not quite. But it felt that way--just like the picture--as if nothing could ever go wrong. The placid park. The bright and dozy day. The neon-blue lake, shimmering in the breeze. Lew McBride was on a long run through the narrow park that follows the shoreline of the Zurichsee from busy Bellevueplatz out to the sub-urbs. He'd already gone about three miles, and was on his way back, jog-ging through the dappled shade, thinking idly of Seurat. The pointillist's great canvas was peopled with respectable-looking men in top hats, docile children, and women in bustles carrying parasols. But the age it captured was two world wars ago, before Seinfeld, the Internet, and "ethnic cleansing." People were different now, and so were Sunday af-ternoons (even, or especially, when they were the same). To begin with, it seemed as if half the girls he saw were on cell-phones, Rollerblades, or both. They had pierced navels and mischievous eyes, and cruised, giggling, past kids with soccer balls, dozing "guest-workers," and lovers making out in the lush grass. The air was fresh from the Alps, sunny, cool and sweet, its soft edge tainted now and then with whiffs of marijuana. He liked Zurich. Being there gave him a chance to practice his German. It was the first language he'd studied, chosen in high school be-cause he'd had a crush on an exchange student. Later, he'd acquired Spanish, picked up a little French, and even some Creole, but German was first--thanks to Ingrid. He smiled at the thought of her--Ingrid of the amazing body--cruising past a marina where sailboats rocked at their moorings, halyards clanking. He could barely hear them. He had the volume turned up on his Walkman, listening to Margo Timmons sing an old Lou Reed song about someone called ". . . Jane . . . Sweet Jane . . ." Music, books, and running were McBride's secret nicotine and, without them, he became restless and unhappy. They were the reason he did not own (could not afford) a sailboat--which he wanted very much. His apartment in San Francisco was a testament to these obses-sions. Near the windows, the stereo and the oversized sofa, stacks of books and CDs stood like dolmens: blues, mornas, DeLillo, and opera. Konpa, rock, and gospel. Chatwin on Patagonia, Ogburn on Shake-speare. And a dozen books on chess, which McBride would rather read about than play (except, perhaps, in Haiti, where he and Petit Pierre sometimes sat for hours in the Oloffson, hunched over a battered chess-board, sipping rum). Thinking about it made him miss it--the place, the chess, his friends . . . As he ran, he glanced at his wristwatch and, seeing the time, picked up the pace. He had about an hour and twenty minutes until his ap-pointment at the Institute, and he didn't like to be late. (In fact, being late drove him crazy.) Headquartered in Kuessnacht, about twenty minutes from McBride's hotel, the Institute of Global Studies was a small, but venerable, think tank funded by old money flowing from tributaries on both sides of the Atlantic. Like so many foundations established in the aftermath of the Second World War, the Institute was dedicated to the idea--the vague and elusive idea--of world peace. Toward that end, it hosted con-ferences and awarded fellowships each year to a handful of brilliant youths whose research interests coincided with the Foundation's own. These included topics as diverse as "the rise of paramilitary formations in Central Africa," "Islam and the Internet," "Deforestation in Nepal," and McBride's own study--which concerned the therapeutic compo-nents of animist religions. With the Cold War a thing of the past, the Foundation's directors had formed the opinion that future conflicts would be "low-intensity" struggles fueled, in most cases, by ethnic and religious differences. With advanced degrees in clinical psychology and modern history, McBride had been traveling for nearly two years. During that time, he'd produced reports on, among other things, the mass-conversion tech-niques of faith healers in Brazil, the induction of trance states in Haitian voodoo ceremonies, and the role of "forest herbs" in the rites of Candomble. Two of these reports had been published in the New York Times Maga-zine, and this had led to a book contract. In three months, his fellowship would be up for renewal and, after thinking it over, he'd decided to take a pass. He was a little tired of living out of suitcases, and ready to focus on writing a book. And since the Foundation had summoned him to Zurich for their annual "chat," it was the perfect opportunity to let them know of his decision in advance. All of which was just another way of saying that life was good-- and getting better. If McBride's meeting went as planned, he could catch the six o'clock flight to London, arriving in time for dinner with Jane herself--the real Jane, whom he hadn't seen in months. "Sweet Jane, Sweet Jane . . ." It was this prospect that spurred his pace, so that he got back to his hotel--the Florida--nearly ten minutes earlier than he'd expected. This gave him plenty of time to shower, shave, and dress, as well as to pack his only bag--a canvas duffel that had seen better days. His meeting was with the Foundation's Director, Gunnar Opdahl, a wealthy and cosmopolitan Norwegian surgeon who had given up medi-cine for philanthropy. Having spoken with Opdahl by telephone from California, McBride knew that the director wanted him to re-up for a third year. He was glad that he had this opportunity to meet with Opdahl face-to-face. It would give him the chance to discuss the reasons behind his decision to leave, while at the same time expressing his gratitude to the Institute. And, while he was at it, he could visit Jane on the way home. The Institute was headquartered in a turn-of-the-century townhouse, a brooding pile of granite built by a Swiss industrialist who had later hanged himself from a chandelier in the foyer (damaging it in the process). The building was three stories tall, with mullioned windows and wavy antique glass. There were copper gutters with gargoyles at the downspouts, a trio of chimneys poking through the tiled roof, and half a dozen window boxes, dripping with flowers. A small brass plaque beside the massive front door declared the Foundation's identity in German, French, and English. Above the leaded glass transom, a closed-circuit television camera stared down as he rang the doorbell once, twice, and-- "Lew!" The door swung open, and Gunnar Opdahl surged into view, eclipsing the room behind him. Taller even than the six foot one McBride, the Institute's director was impeccably dressed in an expensive business suit that had a hand-tailored look, and a Hermes tie that McBride recognized from the duty free shops at Heathrow. Rangy yet solidly built, the fiftyish Opdahl moved with the grace and languor of an aging athlete--which, in fact, he was, having won a bronze medal in the downhill decades earlier. It came up in conversation one time--the strange coincidence that McBride's father had medalled in the same Games (Sapporo, 1972), taking a silver in the biathlon (the first American ever to place in the event). Opdahl had winced good-naturedly, complaining that "Norway owns the biathlon--at least, we're supposed to!" Now, Opdahl shook his hand and clapped a friendly arm around McBride's shoulder. "So how was your trip?" he asked. "No problems?" The older man ushered McBride inside, then pushed the door shut be-hind them. "A little jet lag," McBride replied. "But, no. The flight was fine." "And the Florida?" Opdahl asked, looking bemused as he took McBride's duffel and set it beside the door. "The Florida's great!" Opdahl chuckled. "Large rooms, yes. But, great? I don't think so." McBride laughed. "Well, it's cheap, anyway." Opdahl shook his head, and clucked. "Next time, stay at the Zum Storchen, and let the Foundation worry about the money. I've told you: that's what we do!" McBride made a gesture that was something between a shrug and a nod, and glanced around. The Institute's quarters were more or less as he remembered them, with Persian carpets scattered across the marble floors, coffered ceilings and oak wainscotting, oil paintings of flowers and landscapes, and a scattering of blond PCs on antique wooden desks. Though he'd only been to the Institute twice before, he was surprised to find its headquarters so quiet. Noticing that surprise, Opdahl clapped him on the shoulder, and gestured toward the stairs. "There's just us!" he exclaimed, leading the way. "Really?" "Of course. It's Saturday! No one comes to work on Saturday--except the boss. And that's only because I don't have a choice!" "Why not?" McBride asked, as they began to mount the steps. "If you're 'the boss'--" "Because I live here," Opdahl told him. They ascended the stairs in tandem, heading toward the third floor. "I always assumed you lived in the city," McBride remarked. Opdahl shook his head, and winced. "No. This is . . . what do you say? 'My home-away-from-home.' " He paused on the landing, and turned to ex-plain. "My wife lives in Oslo--hates Switzerland. Says it's too bourgeois." "Well," McBride said, "that's its charm." "Of course, but--one can't argue these things." "And your children?" "All over the place. One boy's at Harvard, another's in Dubai. Daughter's in Rolle." "School?" "Mmmnn. I spend half my life on airplanes, rocketing through the void." "And the rest of the time?" Opdahl flashed a grin, and resumed climbing. "The rest of the time I'm raising money for the Foundation, or sticking pins in maps, trying to keep track of people like you." It was McBride's turn to smile and, as they climbed, he made a joke about being breathless. "I thought there was an elevator," he remarked. "There is, but I don't like to use it on weekends," Opdahl replied. "If there were a power failure . . . well, you can imagine." On his previous visits, McBride had met with Opdahl and his assis-tants in a conference room on the second floor--so he was at least mildly curious about the living quarters overhead. Arriving on the third floor, they came to a door that seemed entirely out of keeping with the build-ing they were in. Made of steel rather than wood, it was unusually thick and sported a brushed aluminum keypad that governed its opening. Opdahl punched three or four numbers, and the door sprung open with a metallic click. The foundation director rolled his eyes. "Ugly, isn't it?" "Well, it's . . . big," McBride remarked. Opdahl chuckled. "The previous tenants were a private bank," he explained. "From what I've heard about their clientele, a big door was probably well advised." The office itself was large and comfortable, brightly lighted and fur-nished in a modern style--unlike the rooms below. There was a wall of books and a leather sofa. A Plexiglas coffee table was laden with a silver tray that held a steaming pot of tea, two cups and saucers, milk and sugar, and a little pile of madeleines. "Tea?" Opdahl asked. McBride nodded--"Please"--and walked to the windows behind the desk, where he marveled at the view. Seen through the trees, the lake was the color of Windex, and glittered like broken glass. "Spectacular," he said. Opdahl acknowledged the compliment with a tilt of his head, pouring the while. "Sugar?" "Just a little milk," McBride replied. And, then, noticing the computer on the director's desk, he cocked his head and frowned. "Where's the A-drive?" he asked. "What's an 'A-drive'?" "For your floppies." "Oh, that!" Opdahl replied. "There isn't one." McBride was genuinely puzzled. "How come?" Opdahl shrugged. "We like to keep our data confidential and, this way, we can be sure it stays in-house." He handed McBride a cup of tea and, sitting down behind the desk, gestured for the young American to take a seat on the couch. Then he sipped, and exclaimed, "So!" A pause. "You've been doing a wonderful job!" "Well . . . thanks," McBride replied. "I mean it, Lewis. I know how difficult it can be to work in places like Haiti. They're filthy, and if you don't know what you're doing, they can be dangerous." "I got my shots." "Still . . ." Opdahl leaned forward, and cleared his throat. "You must be wondering what this is all about. . . ." McBride shifted in his seat, and smiled. "Not really," he said. "I just assumed. The fellowship ends in a couple of months. . . ." Opdahl nodded in a way that confirmed the observation even as he dismissed its relevance. "Well, yes, you're right--of course, but . . . that's not the reason you're here." "No?" McBride gave him a puzzled look. "No." A whirring sound came from the hall outside the office and, hearing it, the two men looked in its direction. "Is that the elevator?" McBride asked. The director nodded, his brow creasing in a frown. "But--" "It's one of the staff," Opdahl supposed. "He probably forgot something." Then the whirring stopped, and they could hear the doors rolling back. A moment later, there was a knock. "Would you mind?" the director asked, gesturing toward the door. McBride frowned. Hadn't Opdahl said, "There's just us"? And something about not using the elevator. But he did as he was asked. "No problem," he said, and, getting to his feet, stepped to the door and opened it. There was only a fraction of a second to take things in, and no time at all to make sense of it. What he saw was this: a man in surgical scrubs with a gas mask over his face. Then a cloud of spray, and the floor rising toward him. A shower of lights. Darkness. Excerpted from The Syndrome by John Case All rights reserved by the original copyright owners. Excerpts are provided for display purposes only and may not be reproduced, reprinted or distributed without the written permission of the publisher.