Cover image for Controlled drug delivery : designing technologies for the future
Controlled drug delivery : designing technologies for the future
Park, Kinam.
Publication Information:
Washington, D.C. : American Chemical Society, [2000]

Physical Description:
xii, 459 pages : illustrations (some color) ; 23 cm.
Format :


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RS199.5 .C664 2000 Adult Non-Fiction Central Closed Stacks

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Despite the public desire for a magic bullet--a drug that cures the ailment and is easy to take--most drugs require a sustained release to the target area as opposed to a burst, hence the need for controlled release devices. This volume devotes separate sections to current work in each of thekey aspects for developing these devices, including the route of administration, drug delivery vehicles, drug targeting, and modulated drug delivery.

Author Notes

Kinam Park is at Purdue University. Randall J. Mrsny is at Genentech, Inc..

Table of Contents

Kinam Park and Randall J. MrsnyJoseph A. Fix and Kazuhiro Sako and Toyohiro SawadaH. E. Junginger and M. Thanou and H. L. Luessen and A. F. Kotze and J. C. VerhoefRonald T. Borchardt and Binghe WangHyo-kyung Han and Gordon L. AmidonAndrea Leone-Bay and Theresa Rivera-Schaub and Rajesh Agarwal and Mark Gonze and Sam Money and Connie Rosado-Gray and Robert A. BaughmanM. X. Duan and J. H. Guo and H. Ma and Y. Zuo and C. X. ZhengAvinash G. ThombreAbraham Rubinstein and Sigal Blau and Paul Bass and Ron KohenA. Ainaoui and E. M. Ouriemchi and J. M. VergnaudTheresa M. AllenWayne R. Gombotz and Dean K. PettitLichun Lu and Susan J. Peter and Georgios N. Stamatas and Antonios G. MikosSannamu Lee and H. Michael Ellerby and Taira Kiyota and Gohsuke SugiharaW. I. Lencer and D. Merlin and A. J. Ouellette and M. E. Selsted and J. L. MadaraMartin C. Peters and David J. MooneyGilbert-Andre Keller and Wenlu Li and Randall J. MrsnyKyung-Dall Lee and Gretchen M. LarsonYon Rojanasakul and Q. Luo and J. Ye and D. Faroonsargn and S. Dokka and X. ShiMitsuru Hashida and Makiya Nishikawa and Fumiyoshi Yamashita and Yoshinobu TakakuraWenjin Guo and Robert J. LeeYang Liu and Qingzhong Kong and Ka-yun Ng and Kevin LilleheiSoon Hong Yuk and Jung Ki Seo and Jin Ho Lee and Sun Hang ChoJeffrey G. Linhardt and David A. TirrellHasan Uludag and Xiao-Dong FanF. Yam and X. Y. Wu and Q. ZhangNeil Ackerman and Bret Berner and Jim Biegajski and Qiang Chen and Hilary Chen and Tom Conn and Hardip Dehal and Tim Dunn and Al Ewing and Steve Fermi and Russell Ford and Priya Jagasia and Yalia Jayalakshmi and Priti Joshi and Brian Kersten and Ronald Kurnik and Tim Lake and Matt Lesho and Jan-Ping Lin and David Liu and Margarita Lopatin and Lexa Mack and Heather Messenger and Sam Morley and Michelle Oliva and Norman Parris and Russell Potts and Jeff Pudlo and Michael Reidy and Pravin Soni and Janet Tamada and Michael Tierney and Christopher Uhegbu and Prema Vijayakumar and Charles Wei and Steve Williams and Don Wilson and Christine WuPanayiotis P. ConstantinidesVladimir P. Torchilin and Volkmar WeissigKishor M. Wasan and Manisha Ramaswamy and Allison L. Kennedy and Kathy Peteherych and Wesley WongKazuhiko IshiharaGopi M. VenkateshRuth DuncanLin Yang and Paschalis AlexandridisTooru Ooya and Nobuhiko YuiHai Bang Lee and Gilson Khang and Jin Cheol Cho and John M. Rhee and Jung Sik LeeAlexander K. Andrianov and Jianping Chen and Sameer S. Sule and Bryan E. RobertsKi-Young Lee and Kun Na and Yu-Eun KimKazuhiko Ishihara and Tomohiro Konno and Kimio Kurita and Yasuhiko Iwasaki and Nobuo Nakabayashi
Prefacep. xi
1. Controlled Drug Delivery: Present and Futurep. 2
Oral Delivery: Design Consideration and Challenges
2. Controlled-Release Oral Delivery Systemsp. 14
3. Safe Mucosal Penetration Enhancers: A Fiction? Polymers as Absorption Enhancers for Transmucosal Drug Deliveryp. 25
4. Prodrug Strategies to Improve the Oral Absorption of Peptides and Peptide Mimeticsp. 36
5. Designing Prodrugs for the hPEPT1 Transporterp. 46
6. Oral Delivery of Heparinp. 54
7. Hypoglycemic Effect of Insulin in Oil Preparation by Oral Administrationp. 65
8. Feasibility Assessment and Rapid Development of Oral Controlled Release Prototypesp. 69
9. The Effect of Adhesive Antioxidant Enzymes on Experimental Colitis in the Ratp. 78
10. Oral Dosage Forms with Controlled Release for Constant Plasma Drug Levelp. 90
Delivery Strategies
11. Solving Drug Delivery Problems with Liposomal Carriersp. 100
12. PEGylation: A Tool to Enhance Protein Deliveryp. 110
13. Polymeric Delivery Vehicles for Bone Growth Factorsp. 124
14. De Novo Design and Synthesis of a Small Globular Protein That Forms a Pore in Lipid Bilayersp. 139
15. Natural Pore Forming Proteins: Paneth Cell Cryptdinsp. 149
16. Growth Factor Delivery from Tissue Engineering Matrices: Inducing Angiogenesis to Enhance Transplanted Cell Engraftmentp. 157
Drug Targeting
17. Targeting Macromolecular Therapeutics to Specific Cell Organellesp. 168
18. Modified Liposome Formulations for Cytosolic Delivery of Macromoleculesp. 184
19. Molecular Targeting of Nuclear Transcriptional Regulatorsp. 193
20. Cell-Specific Targeting of Drugs and Genes with Glycosylated Liposomes: Comparison with Glycosylated Poly(amino acids)p. 201
21. Targeted Gene Delivery via the Folate Receptorp. 212
22. Latest Advances in the Understanding of Active-Specific Immunotherapy for Brain Tumorsp. 220
Modulated Drug Delivery Vehicles
23. Application of pH- and Temperature-Sensitive Polymers for Controlled Drug Release Devicep. 232
24. Characterization of Poly(2-ethylacrylic acid) for Use in Drug Deliveryp. 243
25. Synthesis and Characterization of Thermoreversible, Protein-Conjugating Polymers Based on N-Isopropylacrylamidep. 253
26. A Novel Composite Membrane for Temperature- and pH-Responsive Permeationp. 263
27. Glucose Monitoring via Reverse Iontophoresisp. 273
Delivery Vehicles for Hydrophobic Drugs
28. Self-Emulsifying Drug Delivery Formulations in the 21st Century: Challenges and Opportunitiesp. 284
29. Polymeric Micelles for the Delivery of Poorly Soluble Drugsp. 297
30. The Role of Plasma Lipoproteins as Carriers of Water-Insoluble Compounds: Biological and Physiological Consequencesp. 314
31. Polymeric Lipid Nanosphere Composed of Hemocompatible Phospholipid Polymers as Drug Carrierp. 324
32. Solubility Considerations and Design of Controlled Release Dosage Formsp. 335
Polymeric Drug Delivery Vehicles
33. Polymer Therapeutics into the 21st Centuryp. 350
34. Controlled Release from Ordered Microstructures Formed by Poloxamer Block Copolymersp. 364
35. Supramolecular-Structured Polymers for Drug Deliveryp. 375
36. Fentanyl-Loaded Poly(L-lactide-co-glycolide) Microspheres for Local Anesthesiap. 385
37. Ionically Cross-Linked Polyphosphazene Microspheresp. 395
38. Polysaccharide as a Drug-Coating Polymerp. 407
39. Preparation of Blood-Compatible Nanoparticles Bearing Phosphorylcholine Groupp. 417
Author Indexp. 429
Subject Indexp. 431