Cover image for Merritt's neurology.
Merritt's neurology.
Merritt, H. Houston (Hiram Houston), 1902-1979. Textbook of neurology.
Tenth edition / editor, Lewis P. Rowland.
Publication Information:
Philadelphia : Lippincott Williams & Wilkins, [2000]

Physical Description:
xx, 1002 pages : illustrations ; 29 cm
Format :


Call Number
Material Type
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RC346 .M4 2000 Adult Non-Fiction Non-Fiction Area-Reference

On Order



The thoroughly revised Tenth Edition of this acclaimed classic retains the organization, practicality, and readability that made Merritt's one of the most popular texts among neurologists, primary care providers, and residents reviewing for psychiatry or neurology boards. In 164 short chapters, the book provides the essentials the clinician needs on signs and symptoms, diagnostic tests, and neurologic disorders of all etiologies.This edition reflects recent breakthroughs in molecular genetics, imaging, and research on many diseases. New chapters cover prion diseases, CSF hypotension, superficial siderosis, glucose transporter deficiency, and end-of-life issues. Design improvements include a second color in the text.

Table of Contents

Scott A. Small and Richard MayeuxJ. P. MohrTimothy A. Pedley and Dewey K. ZieglerJohn C. M. BrustLewis P. RowlandJack J. WazenMyles M. BehrensNeil H. RaskinStanley FahnLewis P. RowlandSid GilmanLewis P. RowlandRobert DeLaPaz and Stephen ChanRonald G. Emerson and Thaddeus S. Walczak and Timothy A. PedleyDale J. Lange and Werner TrojaborgJ.P. Mohr and Robert DeLaPazRobert A. FishmanArthur P. HaysYaakov SternLewis P. RowlandJames R. Miller and Burk JubeltGary L. BernardiniBurk Jubelt and James R. MillerCarolyn Barley BrittonLeon D. ProckopJohn C. M. BrustLewis P. Rowland and Leonidas StefanisJames R. MillerJames R. MillerBurk Jubelt and James R. MillerJames R. MillerDarryl C. De VivoBurk JubeltElan D. LouisRalph L. SaccoRandolph S. MarshallJohn C. M. BrustJohn C. M. BrustJ. P. Mohr and Christian StapfAlexander Halim and Ralph L. SaccoFrank M. YatsuMitchell S. V. Elkind and J. P. MohrArnold P. Gold and Abba L. CarganFrank M. YatsuStephan A. Mayer and Gary L. Bernardini and John C. M. Brust and Robert A. SolomonRobert A. FishmanLeon A. WeisbergLeon D. ProckopRobert A. FishmanRobert A. FishmanLeon D. Prockop and Stephan A. MayerCasilda M. BalmacedaJeffrey N. Bruce and Casilda M. Balmaceda and Michael R. FetellCasilda M. Balmaceda and Michael B. Sisti and Jeffrey N. BruceCasilda M. Balmaceda and Robert L. FineCasilda M. BalmacedaJeffrey N. Bruce and Casilda M. Balmaceda and Bennett M. Stein and Michael R. FetellJeffrey N. Bruce and Michael R. Fetell and Pamela U. FredaJames H. Garvin, Jr. and Neil A. FeldsteinRobert A. Solomon and John Pile-Spellman and J. P. MohrCasilda M. BalmacedaPaul C. McCormick and Michael R. Fetell and Lewis P. RowlandStephan A. Mayer and Lewis P. RowlandJoseph T. MarottaPaul C. McCormickLewis P. Rowland and Paul C. McCormickLewis P. Rowland and Paul C. McCormickDale J. Lange and Werner Trojaborg and Lewis P. RowlandLewis P. RowlandJames H. HalseyCasilda M. Balmaceda and Steven R. IsaacsonLewis P. RowlandLeon D. ProckopM. Richard Koenigsberger and Ram KairamThornton B. A. Mason, II and Darryl C. De VivoIsabelle RapinMelvin GreerMelvin GreerLewis P. RowlandChing H. WangJohn H. MenkesLewis P. RowlandWilliam G. JohnsonSalvatore DiMauroDarryl C. De VivoRosario R. Trifiletti and Douglas R. Nordli, Jr.Mia MacCollin and Darryl C. De VivoStefano Di Donato and Graziella UzielJohn H. MenkesLewis P. RowlandTimothy A. Pedley and Lewis P. RowlandLewis P. RowlandEveline C. Traeger and Isabelle RapinLewis P. RowlandEveline C. Traeger and Isabelle RapinSalvatore DiMauro and Eric A. Schon and Michio Hirano and Lewis P. RowlandMyles M. Behrens and Michio HiranoDarryl C. De Vivo and Michio HiranoArnold P. GoldArnold P. GoldArnold P. GoldArnold P. GoldNorman LatovRobert E. Lovelace and Lewis P. RowlandDale J. Lange and Norman Latov and Werner TrojaborgScott A. Small and Richard MayeuxSusan B. Bressman and Timothy Lynch and Roger N. RosenbergStanley FahnStanley FahnStanley FahnStanley FahnStanley Fahn and Susan B. BressmanElan D. Louis and Paul E. GreeneStanley Fahn and Serge PrzedborskiPaul E. GreeneStanley Fahn and Robert E. BurkeLewis P. RowlandLewis P. RowlandElliott L. Mancall and Paul C. McCormickAudrey S. Penn and Lewis P. RowlandAudrey S. PennAudrey S. PennMichio HiranoLewis P. RowlandLewis P. RowlandLewis P. RowlandLewis P. RowlandLewis P. RowlandRobert B. Layzer and Lewis P. RowlandLewis P. RowlandLewis P. RowlandLewis P. RowlandJames R. MillerJames R. MillerGary L. Bernardini and Elliott L. MancallLouis H. WeimerLouis H. WeimerAlan M. AronNeil H. RaskinTimothy A. Pedley and Carl W. Bazil and Martha J. MorrellDouglas R. Nordli, Jr. and Timothy A. PedleyDouglas R. Nordli, Jr. and Timothy A. PedleyJohn C.M. BrustJack J. WazenJune M. FryGary M. Abrams and Earl A. ZimmermanKyriakos P. Papadopoulos and Casilda M. BalmacedaNeil H. Raskin and Lewis P. RowlandEric J. Heyer and Lewis P. RowlandRoger N. RosenbergNeil H. RaskinStephan A. Mayer and Matthew E. FinkLewis P. RowlandLewis P. Rowland and Bradford P. WorrallLewis P. RowlandAlison M. Pack and Martha J. MorrellJohn C.M. BrustJohn C.M. BrustLewis P. RowlandMassimo Corbo and Casilda M. BalmacedaLewis P. RowlandClaudia A. ChiribogaLewis P. RowlandLaura Lennihan and Glenn M. SeligerLewis P. Rowland
Contributing Authorsp. xi
Prefacep. xix
Abbreviationsp. xxi
I. Symptoms of Neurologic Disorders
1. Delirium and Dementiap. 3
2. Aphasia, Apraxia, and Agnosiap. 7
3. Syncope and Seizurep. 12
4. Comap. 17
5. Diagnosis of Pain and Paresthesiasp. 23
6. Dizziness and Hearing Lossp. 26
7. Impaired Visionp. 31
8. Headachep. 36
9. Involuntary Movementsp. 38
10. Syndromes Caused by Weak Musclesp. 42
11. Gait Disordersp. 45
12. Signs and Symptoms in Neurologic Diagnosisp. 50
II. How to Select Diagnostic Tests
13. Computed Tomography and Magnetic Resonance Imagingp. 55
14. Electroencephalography and Evoked Potentialsp. 64
15. Electromyography and Nerve Conduction Studies in Neuromuscular Diseasep. 73
16. Neurovascular Imagingp. 77
17. Lumbar Puncture and Cerebrospinal Fluid Examinationp. 89
18. Muscle and Nerve Biopsyp. 92
19. Neuropsychologic Evaluationp. 94
20. DNA Diagnosisp. 98
III. Infections of the Nervous System
21. Bacterial Infectionsp. 103
22. Focal Infectionsp. 127
23. Viral Infectionsp. 134
24. Acquired Immunodeficiency Syndromep. 163
25. Fungal and Yeast Infectionsp. 175
26. Neurosarcoidosisp. 180
27. Spirochete Infections: Neurosyphilisp. 182
28. Spirochete Infections: Leptospirosisp. 189
29. Spirochete Infections: Lyme Diseasep. 190
30. Parasitic Infectionsp. 192
31. Bacterial Toxinsp. 202
32. Reye Syndromep. 205
33. Prion Diseasesp. 206
34. Whipple Diseasep. 212
IV. Vascular Diseases
35. Pathogenesis, Classification, and Epidemiology of Cerebrovascular Diseasep. 217
36. Examination of the Patient with Cerebrovascular Diseasep. 229
37. Transient Ischemic Attackp. 231
38. Cerebral Infarctionp. 232
39. Cerebral and Cerebellar Hemorrhagep. 240
40. Genetics of Strokep. 241
41. Other Cerebrovascular Syndromesp. 244
42. Differential Diagnosis of Strokep. 247
43. Stroke in Childrenp. 250
44. Treatment and Prevention of Strokep. 257
45. Subarachnoid Hemorrhagep. 260
46. Cerebral Veins and Sinusesp. 268
47. Vascular Disease of the Spinal Cordp. 271
V. Disorders of Cerebrospinal and Brain Fluids
48. Hydrocephalusp. 277
49. Brain Edema and Disorders of Intracranial Pressurep. 284
50. Superficial Siderosis of the Central Nervous Systemp. 291
51. Hyperosmolar Hyperglycemic Nonketotic Syndromep. 292
VI. Tumors
52. General Considerationsp. 297
53. Tumors of the Skull And Cranial Nervesp. 304
54. Tumors of the Meningesp. 311
55. Gliomasp. 318
56. Lymphomasp. 334
57. Pineal Region Tumorsp. 341
58. Tumors of the Pituitary Glandp. 347
59. Congenital and Childhood Central Nervous System Tumorsp. 354
60. Vascular Tumors and Malformationsp. 367
61. Metastatic Tumorsp. 376
62. Spinal Tumorsp. 388
VII. Trauma
63. Head Injuryp. 401
64. Spinal Injuryp. 416
65. Intervertebral Disks and Radiculopathyp. 424
66. Cervical Spondylotic Myelopathyp. 430
67. Lumbar Spondylosisp. 434
68. Peripheral and Cranial Nerve Lesionsp. 436
69. Thoracic Outlet Syndromep. 454
70. Neuropathic Pain and Posttraumatic Pain Syndromesp. 455
71. Radiation Injuryp. 457
72. Electrical and Lightning Injuryp. 463
73. Decompression Sicknessp. 464
VIII. Birth Injuries and Developmental Abnormalities
74. Neonatal Neurologyp. 467
75. Floppy Infant Syndromep. 473
76. Static Disorders of Brain Developmentp. 476
77. Laurence-Moon-Biedl Syndromep. 484
78. Structural Malformationsp. 485
79. Marcus Gunn and Mobius Syndromesp. 498
IX. Genetic Diseases of the Central Nervous System
80. Chromosomal Diseasesp. 503
81. Disorders of Amino Acid Metabolismp. 506
82. Disorders of Purine Metabolismp. 512
83. Lysosomal and Other Storage Diseasesp. 514
84. Disorders of Carbohydrate Metabolismp. 530
85. Glucose Transporter Protein Syndromep. 533
86. Hyperammonemiap. 534
87. Peroxisomal Diseases: Adrenoleukodystropy, Zellweger Syndrome, and Refsum Diseasep. 537
88. Organic Aciduriasp. 541
89. Disorders of Metal Metabolismp. 543
90. Acute Intermittent Porphyriap. 549
91. Neurological Syndromes with Acanthocytesp. 552
92. Xeroderma Pigmentosump. 555
93. Cerebral Degenerations of Childhoodp. 555
94. Diffuse Sclerosisp. 561
95. Differential Diagnosisp. 562
X. Disorders of Mitochondrial DNA
96. Mitochondrial Encephalomyopathies: Diseases of Mitochondrial DNAp. 573
97. Leber Hereditary Optic Neuropathyp. 579
98. Mitochondrial Diseases with Mutations of Nuclear DNAp. 582
XI. Neurocutaneous Disorders
99. Neurofibromatosisp. 587
100. Encephalotrigeminal Angiomatosisp. 591
101. Incontinentia Pigmentip. 594
102. Tuberous Sclerosisp. 596
XII. Peripheral Neuropathies
103. General Considerationsp. 605
104. Hereditary Neuropathiesp. 608
105. Acquired Neuropathiesp. 613
XIII. Dementias
106. Alzheimer Disease and Related Dementiasp. 633
XIV. Ataxias
107. Hereditary Ataxiasp. 645
XV. Movement Disorders
108. Huntington Diseasep. 659
109. Sydenham and Other Forms of Choreap. 662
110. Myoclonusp. 666
111. Gilles de la Tourette Syndromep. 668
112. Dystoniap. 669
113. Essential Tremorp. 678
114. Parkinsonismp. 679
115. Progressive Supranuclear Palsyp. 694
116. Tardive Dyskinesia and Other Neuroleptic-Induced Syndromesp. 696
XVI. Spinal Cord Diseases
117. Hereditary and Acquired Spastic Paraplegiap. 703
118. Hereditary and Acquired Motor Neuron Diseasesp. 708
119. Syringomyeliap. 715
XVII. Disorders of the Neuromuscular Junction
120. Myasthenia Gravisp. 721
121. Lambert-Eaton Syndromep. 727
122. Botulism and Antibiotic-Induced Neuromuscular Disordersp. 728
123. Acute Quadriplegic Myopathyp. 730
XVIII. Myopathies
124. Identifying Disorders of the Motor Unitp. 735
125. Progressive Muscular Dystrophiesp. 737
126. Familial Periodic Paralysisp. 749
127. Congenital Disorders of Musclep. 753
128. Myoglobinuriap. 756
129. Muscle Cramps and Stiffnessp. 758
130. Dermatomyositisp. 763
131. Polymyositis, Inclusion Body Myositis, and Related Myopathiesp. 765
132. Myositis Ossificansp. 770
XIX. Demyelinating Diseases
133. Multiple Sclerosisp. 773
134. Marchiafava-Bignami Diseasep. 792
135. Central Pontine Myelinolysisp. 794
XX. Autonomic Disorders
136. Neurogenic Orthostatic Hypotension and Autonomic Failurep. 799
137. Acute Autonomic Neuropathyp. 802
138. Familial Dysautonomiap. 802
XXI. Paroxysmal Disorders
139. Migraine and Other Headachesp. 807
140. Epilepsyp. 813
141. Febrile Seizuresp. 833
142. Neonatal Seizuresp. 834
143. Transient Global Amnesiap. 836
144. Meniere Syndromep. 837
145. Sleep Disordersp. 839
XXII. Systemic Diseases and General Medicine
146. Endocrine Diseasesp. 849
147. Hematologic and Related Diseasesp. 864
148. Hepatic Diseasep. 876
149. Cerebral Complications of Cardiac Surgeryp. 878
150. Bone Diseasep. 881
151. Renal Diseasep. 886
152. Respiratory Care: Diagnosis and Managementp. 889
153. Paraneoplastic Syndromesp. 893
154. Nutritional Disorders: Vitamin B[subscript 12] Deficiency, Malabsorption, and Malnutritionp. 896
155. Vasculitis Syndromesp. 902
156. Neurologic Disease during Pregnancyp. 911
XXIII. Environmental Neurology
157. Alcoholismp. 921
158. Drug Dependencep. 929
159. Iatrogenic Diseasep. 933
160. Complications of Cancer Chemotherapyp. 936
161. Occupational and Environmental Neurotoxicologyp. 940
162. Abuse of Childrenp. 948
163. Falls in the Elderlyp. 953
XXIV. Rehabilitation
164. Neurologic Rehabilitationp. 957
XXV. Ethical and Legal Guidelines
165. End-of-Life Issues in Neurologyp. 963
Subject Indexp. 967