Cover image for Pharmacokinetics : processes, mathematics, and applications
Title:
Pharmacokinetics : processes, mathematics, and applications
Author:
Welling, Peter G.
Personal Author:
Edition:
Second edition.
Publication Information:
Washington, D.C. : American Chemical Society, [1997]

©1997
Physical Description:
xiv, 393 pages : illustrations ; 24 cm.
General Note:
Previously published in 1986 with subtitle: Processes and mathematics.
Language:
English
Contents:
Pt.1. Drug absorption, distribution, metabolism, and excretion -- Drug absorption, distribution, metabolism, and excretion -- Drug transport -- Parenteral routes of drug administration -- Enteral routes of drug administration -- Factors influencing absorption and bioavailability after enteral administration -- Physicochemical and formulation factors affecting drug absorption -- Clinical factors and interactions affecting drug absorption -- Drug distribution -- Drug metabolism -- Effect of liver disease on drug metabolism and pharmacokinetics -- Renal excretion -- Drug elimination in renal impairment -- Pt.2. The mathematics of pharmacokinetics -- The one-compartment open model with intravenous dosage -- The one-compartment open model with first-order absorption and elimination -- Multiple-dose kinetics -- Metabolite pharmacokinetics -- The two-compartment open model with intravenous or oral administration -- Physiological pharmacokinetic models -- Nonlinear pharmacokinetics -- Pt.3. Applications of pharmacokinetics in drug discovery and development -- Pharmacokinetics and toxicokinetics -- Role of pharmacokinetics in drug discovery and development -- Integration of pharmacokinetics into research and development -- Appendixes -- App.1. Computer methods and software for pharmacokinetic data analysis -- App.2. Worked answers to problem sets --App.3. Nomenclature -- App.4. Glossary.
Subject Term:
ISBN:
9780841234819
Format :
Book

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