Pt.1. Drug absorption, distribution, metabolism, and excretion -- Drug absorption, distribution, metabolism, and excretion -- Drug transport -- Parenteral routes of drug administration -- Enteral routes of drug administration -- Factors influencing absorption and bioavailability after enteral administration -- Physicochemical and formulation factors affecting drug absorption -- Clinical factors and interactions affecting drug absorption -- Drug distribution -- Drug metabolism -- Effect of liver disease on drug metabolism and pharmacokinetics -- Renal excretion -- Drug elimination in renal impairment -- Pt.2. The mathematics of pharmacokinetics -- The one-compartment open model with intravenous dosage -- The one-compartment open model with first-order absorption and elimination -- Multiple-dose kinetics -- Metabolite pharmacokinetics -- The two-compartment open model with intravenous or oral administration -- Physiological pharmacokinetic models -- Nonlinear pharmacokinetics -- Pt.3. Applications of pharmacokinetics in drug discovery and development -- Pharmacokinetics and toxicokinetics -- Role of pharmacokinetics in drug discovery and development -- Integration of pharmacokinetics into research and development -- Appendixes -- App.1. Computer methods and software for pharmacokinetic data analysis -- App.2. Worked answers to problem sets --App.3. Nomenclature -- App.4. Glossary.