Cover image for The human genome : a user's guide
The human genome : a user's guide
Hawley, R. Scott.
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Publication Information:
San Diego, Calif. : Academic Press, [1999]

Physical Description:
xix, 415 pages : illustrations ; 23 cm
Section I. The basics of heredity-- Section II. How genes determine our sex-- Section III. When meiosis of Mendelian inheritance fails-- Section IV. Human genes-- Section V. Interactions of genes and the environment-- Section VI. Prenatal diagnosis
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QH431 .H353 1999 Adult Non-Fiction Central Closed Stacks

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Offering a concise treatment of topics in human genetics, this text begins with coverage of the fundamental concepts of genetics and heredity then illustrates these concepts as they relate to the development of human sexual differentiation and sexuality. The book presents the role of the X and Y chromosomes, the role of hormone-controlled differential gene expression in sex determination, and the role of genetics in sexual orientation and sex-role development.

Reviews 2

Library Journal Review

Using the theme of sexuality, the authors discuss basic genetics information and analytical techniques and the genetic basis of cancer, AIDS, and mental illness. A very complex subject is broken into understandable pieces and then put back together to form a complicated but comprehensible whole. (c) Copyright 2010. Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.

Choice Review

Hawley and Mori have attempted to tread a fine line--to introduce the concept of human genetics to a general audience, while at the same time providing enough depth to allow more than a cursory glance at numerous relevant topics; they have succeeded in their endeavors. The Human Genome provides a thorough grounding. The authors begin with the standard background--the role of Mendel in development of the science of genetics--and continue with the concept of the gene, its duplication and regulation. The transfer of genetic information from genome to protein is explained in a general yet descriptive fashion. The remainder of the book treats the application of these basics. Divided into sections such as "How Genes Determine Sex," to how a variety of mutations or genetic errors result in genetic disease, the book addresses the molecular basis for the most common genetic diseases. The application of new research is also interspersed throughout, including topics such as cloning, cancer, and the potential for gene therapy. Short "subjects" of history and application are boxed into each chapter. Glossary; additional readings. General readers; undergraduates; two-year technical program students. R. Adler; University of Michigan--Dearborn

Table of Contents

Acknowledgmentsp. ix
Prefacep. xi
Section 1 The Basics of Heredityp. 1
Chapter 1 Slaying Molecular Dragons: Brenda's Talep. 3
Chapter 2 The Answer In A Nutshell: Genes, Proteins, and the Basis of Lifep. 7
Chapter 3 Mendel and the Concept of the Genep. 15
Chapter 4 Human Mendelian Geneticsp. 25
Chapter 5 One Man's Trait Is Another Man's Diseasep. 37
Section 2 The Central Dogma of Molecular Biologyp. 45
Chapter 6 DNA: The Genetic Alphabetp. 47
Chapter 7 The Central Dogma of Molecular Biology: How Genes Encode Proteinsp. 55
Chapter 8 Splicing the Modular Genep. 65
Chapter 9 Orchestrating the Human Genomep. 71
Section 3 How Chromosomes Movep. 85
Chapter 10 So What are Chromosomes Anyway?p. 87
Chapter 11 How Cells Move Your Genes Aroundp. 95
Chapter 12 Passing Genes Between Generationsp. 107
Chapter 13 The Chromosomal Basis of Heredityp. 117
Section 4 Mutationp. 125
Chapter 14 Absent Essentials and Monkey Wrenchesp. 127
Chapter 15 How We Detect Mutationsp. 139
Chapter 16 We Are All Mutantsp. 153
Chapter 17 What Constitutes Normal?p. 169
Chapter 18 Mutations in Mammoth Genesp. 177
Chapter 19 Expanded Repeat Traitsp. 187
Section 5 Genes, Chromosomes, and Sexp. 203
Chapter 20 The X and Y Chromosomes: The Odd Couplep. 205
Chapter 21 Genetics of Sex, Gender, and Orientationp. 215
Chapter 22 Aneuploidy: When Too Much or Too Little Countsp. 237
Section 6 Breaking the Rulesp. 253
Chapter 23 Imprintingp. 255
Chapter 24 Imitating Heredity: One Trait, Many Causesp. 265
Section 7 The Human Genome Landscapep. 277
Chapter 25 The Human Genome Projectp. 279
Chapter 26 There's Cloning and Then There's Cloningp. 287
Chapter 27 The Human Genome Sequencep. 299
Chapter 28 Finding Genes in the Human Genomep. 311
Section 8 Complex and Heterogeneous Traitsp. 325
Chapter 29 Genotype Phenotype Correlationsp. 327
Chapter 30 How Complex Can It Get?p. 337
Chapter 31 Quantitative Traitsp. 345
Chapter 32 The MAOA Gene: It There a Genetic Basis for Criminality?p. 353
Chapter 33 The Multiple-Hit Hypothesis: The Genetics of Cancerp. 359
Section 9 Genetic Testing and Therapyp. 377
Chapter 34 Genetic Testing and Screeningp. 379
Chapter 35 Magic Bullets: The Potential for Gene Therapyp. 403
Section 10 Fears, Faith, and Fantasiesp. 419
Chapter 36 Heroes Among Usp. 421
Chapter 37 Fears, Faith, and Fantasiesp. 429
Creditsp. 441
Indexp. 451